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Cholangitis is an infection of the common bile duct, the tube that carries bile from the liver to the gallbladder and intestines. Bile is a chemical made by the liver that helps digest food.
- Causes, incidence, and risk factors
Cholangitis is usually caused by a bacterial infection, which can occur when the duct is blocked by something, such as a gallstone or tumor. The infection causing this condition may also spread to the liver.
Risk factors include a previous history of gallstones, sclerosing cholangitis, HIV, narrowing of the common bile duct, and, rarely, travel to countries where you might catch a worm or parasite infection.
The following symptoms may occur:
- Signs and tests
Tests may include:
- Abdominal ultrasound
- Endoscopic retrograde cholangiopancreatography (ERCP)
- Magnetic resonance cholangiopancreatography (MRCP)
- Percutaneous transhepatic cholangiogram (PTCA)
The following blood tests may be done:
Quick diagnosis and treatment are very important.
Antibiotics to cure infection are tried first for most patients. ERCP or other surgical procedure is done when the patient is stable.
Patients who are very ill or are quickly getting worse may need surgery right away.
- Expectations (prognosis)
The outcome is usually good with treatment, but poor without it.
- Calling your health care provider
Call for an appointment with your health care provider if you have symptoms of cholangitis.
Treatment of gallstones, tumors, and infestations of parasites may reduce the risk for some people. A metal or plastic stents within the bile system may be needed to prevent recurrence.
Attasaranya S, Fogel EL.. Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. Medical Clinics of North America. 2008 Jul;92(4).
Afdhal NH. Diseases of the gallbladder and bile ducts. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 159.
Review Date: 9/20/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.