Christie Clinic - Medicine for Your Life

Our website is currently having technical difficulties. To view the site, please click here

Health Encyclopedia

Health Encyclopedia

An invaluable resource of health information.

Cushing syndrome due to adrenal tumor

Cushing syndrome due to adrenal tumor is an endocrine system disorder that occurs when there is a tumor of the adrenal gland releasing excess amounts of the hormone cortisol.

  • Alternative Names

    Adrenal tumor - Cushing syndrome

  • Causes, incidence, and risk factors

    Cushing syndrome is caused by constant, high levels of the steroid hormone cortisol. A tumor on one of the adrenal glands causes about 15% of all cases of Cushing syndrome. Adrenal tumors release cortisol.

    Adrenal tumors may be noncancerous (benign) or cancerous (malignant).

    Noncancerous tumors that may cause Cushing syndrome include:

    • Adrenal adenomas
    • Micronodular hyperplasia

    Cancerous tumors that may cause Cushing syndrome include:

    Adrenal tumors are rare. They may develop in anyone at any age, but are much more common in adults. They are found in women more often than men.

    See also:

  • Symptoms

    Symptoms usually include:

    • Upper body obesity (above the waist) and thin arms and legs
    • Round, red, full face (moon face)
    • Slow growth rate in children

    Skin changes that are often seen:

    • Acne or skin infections
    • Purple marks (1/2 inch or more wide) called striae on the skin of the abdomen, thighs, and breasts
    • Thin skin with easy bruising

    Muscle and bone changes include:

    • Backache, which occurs with routine activities
    • Bone pain or tenderness
    • Collection of fat between the shoulders (buffalo hump)
    • Thinning of the bones, which leads to rib and spine fractures
    • Weak muscles

    Women often have:

    Men may have:

    • Decreased fertility
    • Decreased or no desire for sex
    • Impotence

    Other symptoms that may occur include:

  • Signs and tests

    Tests to confirm Cushing syndrome:

    Tests to determine cause:

    Other findings may include:

  • Treatment

    Cushing syndrome due to an adrenal tumor is treated with surgery to remove the tumor and often the entire adrenal gland.

    Glucocorticoid replacement treatment is usually needed until the other adrenal gland recovers from surgery. You may need this treatment for 9 - 12 months.

    If surgery is not possible (such as in cases of adrenal cancer), medicines can be used to stop the release of cortisol. These include:

    • Aminoglutethimide
    • Ketoconazole
    • Mifepristone
    • Mitotane

    Radiation therapy usually does not work for cancerous adrenal tumors and is not appropriate for noncancerous tumors.

  • Expectations (prognosis)

    Patients with an adrenal tumor who have surgery have an excellent outlook. Surgery success rates are very high with this type of tumor.

    For adrenal cancer, surgery is sometimes not possible. When surgery is performed, it does not always cure the cancer.

  • Complications

    Cancerous adrenal tumors can spread to the liver or lungs.

  • Calling your health care provider

    Call your health care provider if you develop any symptoms of Cushing syndrome.

  • Prevention

    Appropriate treatment of adrenal tumors may reduce the risk of complications in some patients with tumor-related Cushing syndrome.

  • References

    Stewart PM. The adrenal cortex. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR. Williams Textbook of Endocrinology. 11th ed. Philadelphia, PA: Elsevier; 2008:chap 14.

Review Date: 11/23/2009

Reviewed By: Ari S. Eckman, MD, Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2014 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com
Christie Clinic at the Family Medical Center in Paris
727 East Court Street Paris, IL 61944 Dermatology: 366-1248; Vein and Vascular: 366-2670
Christie Clinic Christie Clinic on University Photo Christie Clinic on University
101 West University Avenue Champaign, IL 61820 Main Phone: (217) 366-1200
Billing Services: (217) 366-1382
Toll Free: (888) 391-0412
Christie Clinic Christie Clinic on Windsor/Convenient Care Photo Christie Clinic on Windsor/Convenient Care
1801 West Windsor Road Champaign, IL 61822 (217) 366-8000
Christie Clinic Christie Clinic at Presence Covenant Photo Christie Clinic at Presence Covenant
1400 West Park Street Urbana, IL 61801 (217) 366-1200
Christie Clinic Christie Clinic in Rantoul Photo Christie Clinic in Rantoul
209 West Borman Drive Rantoul, IL 61866 (217) 892-9671
Christie Clinic Christie Clinic in Mahomet/Convenient Care Photo Christie Clinic in Mahomet/Convenient Care
1001 Commercial Drive Mahomet, IL 61853 Main Number: (217) 586-6600 Convenient Care: (217)366-8130
Christie Clinic Christie Clinic in Danville on Vermilion/Convenient Care Photo Christie Clinic in Danville on Vermilion/Convenient Care
3545 North Vermilion Street Danville, IL 61832 (217) 442-8611
Christie Clinic Christie Clinic in Tuscola Photo Christie Clinic in Tuscola
300 North Main Street Tuscola, IL 61953 (217) 253-9258
Christie Clinic CU Sleep Photo CU Sleep
1207 South Mattis Avenue Champaign, IL 61821 (217) 355-1684
Christie Clinic Christie Clinic Cancer Center Photo Christie Clinic Cancer Center
109 West University Avenue Champaign, IL 61820 (217) 366-5180
Christie Clinic Convenient Care in County Market (Kirby & Duncan) Photo Convenient Care in County Market (Kirby & Duncan)
2901 West Kirby Avenue Champaign, IL 61821 (217) 366-8130
Christie Clinic Christie Clinic in Urbana/Convenient Care Photo Christie Clinic in Urbana/Convenient Care
1710 East Windsor Road Urbana, IL 61802 (217) 344-9440
Christie Clinic Christie Clinic in Danville on Logan Photo Christie Clinic in Danville on Logan
800 North Logan Avenue Danville, IL 61832 (217) 431-8930
Christie Clinic Christie Clinic on Fox Drive Photo Christie Clinic on Fox Drive
2110 Fox Drive, Suite B Champaign, IL 61820
Christie Clinic Christie Clinic in Monticello at Kirby Medical Group Specialty Clinic Photo Christie Clinic in Monticello at Kirby Medical Group Specialty Clinic
1109 B North State Street Monticello, IL 61856 (217) 366-1304
Gibson Area Hospital
1120 N Melvin Gibson City, IL 60936 (217) 784-2240
Christie Clinic Christie Clinic in Mattoon Photo Christie Clinic in Mattoon
105 B Professional Plaza Mattoon, IL 61938 (217) 345-3000
Christie Clinic Sarah Bush Lincoln Health System Photo Sarah Bush Lincoln Health System
1000 Health Center Drive Mattoon, IL 61938 (217) 258-2588
Christie Clinic The Champaign SurgiCenter Photo The Champaign SurgiCenter
1702 S. Mattis Avenue Champaign, IL 61821 (217) 326-2030
Christie Clinic The Carle Foundation Hospital Photo The Carle Foundation Hospital
611 West Park Street Urbana, IL 61801 (217) 383-3311
Iroquois Memorial Hospital
200 E. Fairman Ave. Watseka, IL 60970 (815) 432-5841
Christie Clinic Christie Clinic in Savoy Photo Christie Clinic in Savoy
501 North Dunlap Avenue Savoy, IL 61874 Transformations: (217) 366-7460 Internal Medicine: (217) 366-5434 Ophthalmology: (217) 366-1250
Christie Clinic on West Park Street
1405 West Park Street Urbana, IL 61801 217-366-1237
Christie Clinic in Monticello
107 West Main Street Monticello, IL 61856 217.762.3352
Christie Clinic Christie Clinic in Decatur Photo Christie Clinic in Decatur
100 South Water Street Suite 103 Decatur, IL 62523 217-362-0661- telephone