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Health Encyclopedia

Health Encyclopedia

An invaluable resource of health information.

Congenital protein C or S deficiency

Congenital protein C or S deficiency is a lack of proteins C or S in the fluid part of the blood. The proteins are natural substances that help prevent blood clots.

  • Alternative Names

    Protein S deficiency; Protein C deficiency

  • Causes, incidence, and risk factors

    Congenital protein C or S deficiency is an inherited disorder, which means it is passed down through families. Congenital means it is present at birth.

    The disorder causes abnormal blood clotting.

    About 1 out of every 300 people has one normal gene and one faulty gene for protein C deficiency.

    Protein S deficiency occurs in about 1 in 20,000 people.

  • Symptoms

    If you have this condition, you are more likely to develop blood clots. The symptoms are the same as for deep venous thrombosis, and include:

    • Pain or tenderness in the affected area
    • Redness or swelling in the affected area
  • Signs and tests

    Laboratory tests will be done to check for proteins C and S. If you have this disorder, you will have a lack of protein C or S.

    Other tests that may be done include:

  • Treatment

    Blood-thinning drugs (heparin and warfarin) are used to treat and prevent blood clots.

  • Expectations (prognosis)

    The outcome is usually good with treatment, but symptoms may return.

  • Complications

    In rare cases, using warfarin to thin the blood and prevent clots can cause brief increased clotting and severe skin wounds. Patients are at risk if they are not treated with the blood-thinning drug heparin before taking warfarin.

  • Calling your health care provider

    Call your health care provider if you have symptoms of clotting in a vein (such as swelling and redness of the leg).

  • Prevention

    If your health care provider diagnoses you with this disorder, you should be careful to prevent clots from forming. This can occur when the blood moves slowly in the veins, such as from prolonged bed rest during an illness, surgery, or hospital stay.

  • References

    Schafer AI. Thrombotic disorders: hypercoagulable states. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 182.

Review Date: 11/8/2008

Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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727 East Court Street Paris, IL 61944 Dermatology: 366-1248; Vein and Vascular: 366-2670
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101 West University Avenue Champaign, IL 61820 Main Phone: (217) 366-1200
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1801 West Windsor Road Champaign, IL 61822 (217) 366-8000
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1400 West Park Street Urbana, IL 61801 (217) 366-1200
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209 West Borman Drive Rantoul, IL 61866 (217) 892-9671
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1001 Commercial Drive Mahomet, IL 61853 Main Number: (217) 586-6600 Convenient Care: (217)366-8130
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300 North Main Street Tuscola, IL 61953 (217) 253-9258
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1207 South Mattis Avenue Champaign, IL 61821 (217) 355-1684
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109 West University Avenue Champaign, IL 61820 (217) 366-5180
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2901 West Kirby Avenue Champaign, IL 61821 (217) 366-8130
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1710 East Windsor Road Urbana, IL 61802 (217) 344-9440
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800 North Logan Avenue Danville, IL 61832 (217) 431-8930
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2110 Fox Drive, Suite B Champaign, IL 61820
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1120 N Melvin Gibson City, IL 60936 (217) 784-2240
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105 B Professional Plaza Mattoon, IL 61938 (217) 345-3000
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1000 Health Center Drive Mattoon, IL 61938 (217) 258-2588
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611 West Park Street Urbana, IL 61801 (217) 383-3311
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501 North Dunlap Avenue Savoy, IL 61874 Transformations: (217) 366-7460 Internal Medicine: (217) 366-5434 Ophthalmology: (217) 366-1250
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1405 West Park Street Urbana, IL 61801 217-366-1237
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107 West Main Street Monticello, IL 61856 217.762.3352
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100 South Water Street Suite 103 Decatur, IL 62523 217-362-0661- telephone
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3545 North Vermilion Street Danville, IL 61832 (217) 442-8611