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CSF myelin basic protein
CSF myelin basic protein is a test to measure the level of myelin basic protein (MBP) in the cerebrospinal fluid (CSF), the clear liquid that surrounds the brain and spinal cord.
MBP is found in the material that covers your nerves.
Other methods of collecting CSF are rarely used, but may be recommended in some cases. They include:
- Cisternal puncture
- Ventricular puncture
- Removing CSF from a tube already in place in the CSF, such as a shunt or ventricular drain
After the sample is taken, it is sent to a laboratory for evaluation.
- How the test is performed
See: Lumbar puncture.
- How the test will feel
For detailed information, see the article on lumbar puncture.
- Why the test is performed
This test is done to see if myelin, the substance covering your nerves, is breaking down. Myelin breakdown is called demyelination. Multiple sclerosis is the most common cause for this, but other causes may include:
- Normal Values
In general there should be less than 4 ng/mL of myelin basic protein in the CSF.
Note: ng/mL = nanogram per milliliter
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
- What abnormal results mean
- What the risks are
For information on the risks of spinal tap, see: Lumbar puncture and CSF collection.
Griggs RC, Jozefowicz RF, Aminoff MJ. Approach to the patient with neurologic disease. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier. 2007: chap 418.
Review Date: 6/24/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Daniel B. Hoch, PhD, MD, Assistant Professor of Neurology, Harvard Medical School, Department of Neurology, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.