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Creatinine - blood

Creatinine is a breakdown product of creatine, which is an important part of muscle. This article discusses the laboratory test to measure the amount of creatinine in the blood.

Creatinine can also be measured with a urine test. See: Creatinine - urine

  • Alternative Names

    Serum creatinine

  • How the test is performed

    Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.

    Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.

    Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

    In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.

  • How to prepare for the test

    The health care provider may tell you to stop taking certain drugs that may affect the test. Such drugs include:

    • Aminoglycosides (for example, gentamicin)
    • Cimetidine
    • Heavy metal chemotherapy drugs (for example, Cisplatin)
    • Kidney damaging drugs such as cephalosporins (for example, cefoxitin)
    • Trimethoprim
  • How the test will feel

    When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

  • Why the test is performed

    The test is done to evaluate kidney function. Creatinine is removed from the body entirely by the kidneys. If kidney function is abnormal, creatinine levels will increase in the blood (because less creatinine is released through your urine).

    Creatinine levels also vary according to a person's size and muscle mass.

  • Normal Values

    A normal value is 0.8 to 1.4 mg/dL.

    Females usually have a lower creatinine than males, because they usually have less muscle mass.

    Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

  • What abnormal results mean

    Higher-than-normal levels may indicate:

    Lower-than-normal levels may indicate:

    • Muscular dystrophy (late stage)
    • Myasthenia gravis

    Additional conditions under which the test may be performed:

  • What the risks are
    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)
    • Multiple punctures to locate veins
  • References

    Bazari H. Approach to the patient with renal disease. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 115.

Review Date: 8/7/2009

Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2014 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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