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Chloride - urine

Chloride is a negatively charged molecule known as an electrolyte. It works with other electrolytes, such as potassium, salt (sodium), and carbon dioxide (CO2), to help keep the proper balance of body fluids and maintain the body's acid-base balance.

A test can be done to measure the amount of chloride in a urine sample.

See also:

  • Alternative Names

    Urinary chloride

  • How the test is performed

    A random urine sample or 24-hour urine collection may be needed.

    If a 24-hour urine sample is needed:

    • On day 1, urinate into the toilet when you get up in the morning.
    • Afterwards, collect all urine in a special container for the next 24 hours.
    • On day 2, urinate into the container when you get up in the morning.
    • Cap the container. Keep it in the refrigerator or a cool place during the collection period.
    • Label the container with your name, the date, the time of completion, and return it as instructed.

    For an infant, thoroughly wash the area around the urethra. Open a urine collection bag (a plastic bag with an adhesive paper on one end), and place it on the infant. For males, place the entire penis in the bag and attach the adhesive to the skin. For females, place the bag over the labia. Diaper as usual over the secured bag.

    This procedure may take a couple of attempts -- lively infants can move the bag, causing the urine to be absorbed by the diaper. Check the infant frequently and change the bag after the infant has urinated into it. Drain the urine from the bag into the container provided by your health care provider.

    Deliver it to the laboratory or your health care provider as soon as possible upon completion.

  • How to prepare for the test

    The health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test.

    Drugs that may decrease the level of chloride in the urine chloride include:

    • Acetazolamide
    • Nonsteroidal anti-inflammatory drugs

    Drugs that may increase the level of chloride in the urine chloride include:

    • Corticosteroids
    • Diuretics
  • How the test will feel

    The test involves only normal urination, and there is no discomfort.

  • Why the test is performed

    Your doctor may order this test if you have signs of a disturbance in your body's fluid level or acid-base balance. It may be used to help determine the causes of hypokalemia, and to aid in the diagnosis of renal tubular acidosis.

  • Normal Values

    The normal range is 20 to 250 milliequivalents per day (mEq/day). This range depends greatly on your salt intake and how hydrated you are.

    Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

  • What abnormal results mean

    Increased urine chloride levels may be caused by:

    • Adrenocortical insufficiency
    • Increased salt intake
    • Inflammation of the kidney that results in salt loss
    • Production of an unusually large amount of urine

    Decreased urine chloride levels may be due to:

    • Cushing syndrome
    • Decreased salt intake
    • Fluid loss that occurs with diarrhea, vomiting, sweating, and gastric suction
    • Salt retention
  • What the risks are

    There are no risks.

  • References

    Fukagawa M, Kurokawa K, Papadakis MA. Fluid and electrolyte disorders. In: McPhee SJ, Papadakis MA, Tierney LM, Jr. Current Medical Diagnosis and Treatment 2007. New York, NY: McGraw Hill; 2007.

    Bazari H. Approach to the patient with renal disease. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 115.

Review Date: 8/7/2009

Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2014 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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