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CSF-VDRL test

The CSF-VDRL test is used to diagnose neurosyphilis. This test looks for antibodies called reagins, which are sometimes produced by the body in reaction to the syphilis-causing bacteria.

See also: VDRL

  • Alternative Names

    Venereal disease research laboratory slide test - CSF

  • How the test is performed

    The test is performed on a CSF sample obtained by lumbar puncture (spinal tap).

  • How to prepare for the test

    Before the procedure, you will be asked to review the risks and sign a consent form.

  • How the test will feel

    Usually, discomfort associated with the lumbar puncture is mild to moderate. The entire procedure usually takes about 30 minutes but may take longer. The actual fluid collection only takes a few minutes.

  • Why the test is performed

    The CSF-VDRL test is used to diagnose syphilis in the brain or spinal cord. Brain and spinal cord involvement usually indicates late stage (tertiary) syphilis.

    Blood screening tests, such as VDRL and RPR, are more effective during middle stage (secondary) syphilis.

  • Normal Values

    A negative result is normal.

    However, false-negatives can occur. This means you can have syphilis and have a normal CSF-VDRL test result. Therefore, a negative test does not always rule out the disease. Other markers of inflammation, such as elevated protein levels or excess white blood cells, may be used to diagnose neurosyphilis.

  • What abnormal results mean

    A positive result is abnormal and indicates neurosyphilis.

  • What the risks are

    Risks of lumbar puncture include:

    • Hypersensitivity (allergic) reaction to the anesthetic
    • Discomfort during the test
    • Headache after the test
    • Bleeding into the spinal canal
    • Brain herniation (if performed on a person with increased intracranial pressure) which may result in brain damage or death
    • Damage to the spinal cord or nerve roots
  • References

    Hook EW III. Syphilis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 340.

    Fletcher JJ, Nathan BR. Cerebrospinal fluid and intracranial pressure. In: Goetz, CG, eds. Textbook of Clinical Neurology. 3rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 26.

Review Date: 7/27/2009

Reviewed By: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2014 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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