Factitious hyperthyroidism

• Alternative Names

  Factitious thyrotoxicosis; thyrotoxicosis factitia; thyrotoxicosis medicamentosa

• Causes, incidence, and risk factors

  The thyroid gland produces the hormones thyroxine (T4) and triiodothyronine (T3). In most cases of hyperthyroidism, the thyroid gland itself produces too much of these hormones.

  However, hyperthyroidism can also be caused by taking too much thyroid hormone medication for hypothyroidism. This is called factitious hyperthyroidism. When this occurs because the prescribed dose of hormone medication is too high, it is called iatrogenic, or "doctor-induced," hyperthyroidism.

  Factitious hyperthyroidism can also occur when a patient intentionally takes too much thyroid hormone, such as in people:

  • Who have psychiatric disorders such as Munchausen syndrome
  • Who are trying to lose weight
  • Who want to get compensation from the insurance company

  Children may take thyroid hormone pills accidentally.

  In rare cases, factitious hyperthyroidism is caused by eating meat contaminated with thyroid gland tissue.

• Symptoms

  The symptoms of factitious hyperthyroidism are the same as those of hyperthyroidism caused by the thyroid gland, with these exceptions:

  • There is no goiter. The thyroid gland is usually small.
  • The eyes do not bulge, as they do in Graves disease (the most common type of hyperthyroidism).
  • The skin over the shins does not thicken, as it occasionally does with people who have Graves disease.
• Signs and tests

  The following test results may indicate factitious hyperthyroidism:

  • High levels of free T4
  • High levels of total T3
  • High levels of total T4
  • Low radioactive iodine uptake
  • Low levels of thyroglobulin
  • Low levels of TSH
• Treatment

  You must stop taking thyroid hormone. If it is medically necessary, the dose must be reduced.

  You should be re-evaluated in 2 - 4 weeks to be sure that the signs and symptoms of hyperthyroidism are gone. This also helps to confirm the diagnosis.

  People with Munchausen syndrome will need psychiatric treatment and follow-up.

• Expectations (prognosis)

  Factitious hyperthyroidism will clear up on its own when you stop taking or lower the dose of thyroid hormone.

• Complications

  When factitious hyperthyroidism lasts a long time, patients are at risk for the same complications of untreated or improperly treated hyperthyroidism caused by the thyroid gland.

  These complications include:

  • Atrial fibrillation
  • Chest pain (angina)
  • Heart attack
  • Irregular heart rhythm
  • Loss of bone mass (if severe, osteoporosis)
  • Weight loss
• Calling your health care provider

  Contact your health care provider if you experience any of the symptoms of hyperthyroidism.

• Prevention

  Thyroid hormone should be taken only by prescription and under the supervision of a licensed physician.

Review Date: 6/17/2008

Reviewed By: Elizabeth H. Holt, MD, PhD, Assistant Professor of Medicine, Section of Endocrinology and Metabolism, Yale University. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.