Malignant teratoma

• Alternative Names

  Dermoid cyst - malignant; Nonseminomatous germ cell tumor - teratoma; Immature teratoma

• Causes, incidence, and risk factors

  Malignant teratoma occurs most often in young men in their 20s - 30s. It is often located in the chest area. Most malignant teratomas can spread throughout the body, and have spread by the time of diagnosis.

  A number of other cancers are often associated with these tumors, including:

  • Acute myelogenous leukemia (AML)
  • Embryonal rhabdomyosarcoma
  • Malignant histiocytosis
  • Myelodysplasia (MDS)
  • Small cell undifferentiated carcinoma
• Symptoms

  Symptoms include:

  • Chest pain
  • Cough
  • Fatigue
  • Limited ability to tolerate exercise
  • Shortness of breath
• Signs and tests

  The health care provider will perform a physical exam, which may reveal signs of congestive heart failure and increased pressure in the chest area.

  The following tests help diagnose the tumor:

  • CT scans of the chest, abdomen, and pelvis
  • Blood tests to check beta-HCG and alpha fetoprotein (AFP) levels
  • Mediastinoscopy with biopsy
• Treatment

  Chemotherapy is used to treat the tumor. A combination of medicines (usually cisplatin, etoposide, and bleomycin) is commonly used.

  After chemotherapy is complete, CT scans are taken again to see if any mass remains. Surgery may be recommended if there is a possibility that the cancer will grow back in that area.

• Support Groups

  There are many support groups available for people with cancer. Contact the American Cancer Society -- www.cancer.org

• Expectations (prognosis)

  The outlook depends on the tumor size and location and the age of the patient.

• Complications

  The cancer can spread throughout the body and there may be complications of surgery or related to chemotherapy.

• Calling your health care provider

  Call your health care provider if you have symptoms of malignant teratoma.

Review Date: 9/30/2008

Reviewed By: James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.