Pseudotumor cerebri

• Alternative Names

  Idiopathic intracranial hypertension; Benign intracranial hypertension

• Causes, incidence, and risk factors

  The condition occurs more frequently in women than men, particularly in premenopausal obese women. It is rare in infants.

  The cause is unknown. Certain medicines can increase your risk for this condition. These medicines include:

  • Birth control pills
  • Tetracycline
  • Nitrofurantoin
  • Phenytoin
  • Sulfa drugs
  • Isotretinoin
  • Minocycline
  • Tamoxifen
  • Nalidixic acid
  • Lithium
  • Steroids (starting or stopping them)

  The following factors also associated with this condition:

  • Anemia from iron deficiency
  • Being overweight or obese
  • Chronic kidney failure
  • Cushing’s disease
  • Hypoparathyroidism
  • Hypothyroidism
  • Onset of menstruation (menarche)
  • Pregnancy
  • Vitamin A (too much or too little)
• Symptoms

  The major symptom is increased pressure within the skull (increased intracranial pressure). There is no evidence of tumor, infection, blocked drainage of the fluid surrounding the brain, or any other cause.

  Symptoms include:

  • Headache
  • Buzzing sound in the ears (tinnitus)
  • Dizziness
  • Nausea
  • Double vision (diplopia)
  • Partial or permanent loss of vision. Patients often complain of blurred vision.

  Symptoms may get worse during physical activity, especially when tightening the stomach muscles.

• Signs and tests

  The doctor will perform a physical exam. Signs of this condition include:

  • Swelling of a small area in the back of the eye (papilledema)
  • Increased head size
  • Bulging anterior fontanelle in babies whose cranial sutures are not yet closed

  Despite the increased pressure in the skull, there is no change in alertness.

  Tests that may be done include:

  • CT Scan
  • MRI
  • Lumbar puncture (spinal tap)
  • Eye exam, including formal visual field testing

  The diagnosis is made when other health conditions are ruled out. Several conditions may cause increased intracranial pressure, including venous sinus thrombosis, hydrocephalus, and an intracranial mass (such as a tumor).

• Treatment

  Treatment must be directed at the specific cause of the pseudotumor.

  A lumbar puncture can help relieve pressure within the brain and prevent vision problems.

  Other treatments may include:

  • Fluid or salt restrictions
  • Medications such as corticosteroids, glycerol, acetazolamide, and furosemide
  • Shunting procedures to relieve pressure due to spinal fluid retention
  • Surgery to relieve pressure on the optic nerve
  • Weight loss

  The patient will need their vision closely monitored, since there is potential for progressive and sometimes permanent visual loss. Follow-up MRI or CT scans may be done to rule out hidden cancer.

• Expectations (prognosis)

  Sometimes the condition disappears on its own within 6 months. About 10-20% of persons have their symptoms return. A small number of patients have symptoms that slowly get worse and lead to blindness.

• Complications

  Vision loss is a serious complication of this condition.

• Calling your health care provider

  Call your health care provider if you or your child experience the symptoms listed above.

• References

  Jonnalagadda J. Lithium, minocycline, and pseudotumor cerebri. J Am Acad Child Adolesc Psychiatry. March 1, 2005; 44(3): 209.

  Behrman RE. Nelson Textbook of Pediatrics. 17th ed. Philadelphia, Pa: WB Saunders; 2004; 2048-2049.

Review Date: 3/26/2009

Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Daniel B. Hoch, PhD, MD, Assistant Professor of Neurology, Harvard Medical School, Department of Neurology, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.