Venture - COPD Study Sponsor and Protocol Number: Upstream Bio, Inc. / UPB-CP-06 - VENTURE Specialty: Pulmonology Type: Investigational Drug Inclusion:Age >40 to 2 moderate or >1 severe exacerbations within the yearRequired background triple therapy (ICS, LABA, LAMA) Exclusion: Moderate or severe COPD exacerbation within 4 weeks prior to Screening for the trialTreatment with oxygen of >4 L/minute (nocturnal oxygen use for sleep apnea is allowed)Current diagnosis of asthma